Abstract
Intrapleural injections of aleuronat suspensions into rabbits caused a marked rise of serum globulins and a consequent upset of the protein quotient. Injection of ten cubic centimeters of blood serum from these animals into normal rabbits did not produce appreciable changes in the serum proteins of the latter animals. Apparently there is no factor concerned in the upset of the normal protein quotient which can be transmitted by injection of such homologous sera.
Injection of ten cubic centimeters of 1 : 30,000 homologous typhoid agglutinating serum intravenously into a normal rabbit caused a very slight, non-persistant rise of globulins in the serum of the injected animal. A normal rabbit which received ten cubic centimeters of 1 : 7,000 homologous staphylococcus agglutinating serum showed no change in the protein quotient. The results are essentially in accord with previous work on the non-dependence of immunity on the ratio of serum proteins. Apparently, to produce a decided change in the protein quotient a substance must be injected which causes a marked reaction in the injected animal. This is not accomplished by injection of homologous sera.
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