Suppression of Lymphocyte Transformation by 16,(16) Dimethyl Prostaglandin E 2 and Unsaturated Fatty Acids 1

Abstract

Summary

A new synthetic prostaglandin (16, 16-PGE₂) and unsaturated fatty acids have been shown to inhibit the incorporation of [³H]thymidine in the lymphocyte transformation reaction in response to phyto-hemagglutinin (PHA). This inhibition was not due to toxicity of these substances, for the lymphocytes remained intact and capable of excluding trypan blue.