Abstract
Summary
The growth-inhibitory activity against H. Ep. # 2 cells observed in phosphate buffer extracts of rat liver appears to be due to the enzyme, arginase. This conclusion is based on the findings that (1) extracts of hepatomas containing lower levels of the enzyme also contain less inhibitory activity; (2) partial purification of the inhibitory factor results in a similar purification of the enzyme; (3) molecular weights of the enzyme and of the inhibitory factor are similar; and (4) various treatments alter the enzyme and inhibitory activities similarly.
Supported in part by USPHS Grant CA 10729. The authors acknowledge the valuable technical support of Mrs. C. M. Jackson, Ms. Louise Lawson, and Ms. Tommie Lou Barker.
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