Induced Adrenal and Ovarian Enlargement in Nursing Mothers by a Single μg Injection to their Pups of a 3β-Hydroxy-δ 5 -Steroid Oxidoreductase Inhibitor 1

Abstract

Summary

Isoxazole-¹⁴C, a potent inhibitor of 3β-hydroxy-δ⁵-steroid oxidoreductase, injected into nursing pups is naturally transferred to their mother where it is retained, for at least a month, in ng quantities in the adrenals and ovaries and results in adrenal, ovarian, preputial and pituitary enlargement.