Hepatic Potassium Movements Induced by Sympathomimetic Amines Before and After Adrenergic Blockade 1

Abstract

Summary

The hepatic K⁺-mobilizing effects of phenylephrine and isoproterenol were studied in dogs equipped with chronic indwelling portal vein catheters. Animals anesthetized with sodium pentobarbital, received intraportal injections of these sympathomimetic amines, alone or in combination, before and after α, or β, or combined adrenergic blockade. Hepatic K⁺ movements were assessed by measuring systemic arterial and hepatic venous K⁺ levels. It was concluded that adrenergic blockade exerted no significant influence on the ability of these agents to provoke the initial release and subsequent uptake of K⁺ by the liver.