Abstract
Summary
Male Japanese quail castrated and treated with β-estradiol-3-benzoate for 3 wk were more resistant than sham-operated males to the necrogenic effects of massive doses of isoproterenol.
The estrogen-treated castrate also weighed significantly more and had significantly lower hematocrit ratios than either the sham-operated male or the intact male. These results indicate that there is a definite sex-related protective effect against this type of cardiac necrosis which cannot be explained on the basis of differences in body weight.
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