Abstract
Summary
The concentrations of triglyc-eride in the blood of female rats increased 2-and 4-fold during treatment with 5 and 15 μg/kg of ethynyl estradiol, respectively. The rate of secretion of triglyceride increased 66 % over controls with livers obtained from the rats administered ethynyl estradiol. Ethynyl estradiol induced a hypocholesterolemia in the donor animals but the secretion of cholesterol into the perfusate from livers obtained from these animals was not affected. Adrenal corticosterone levels were depressed 48% in animals receiving ethynyl estradiol. The hypertriglyceridemia is produced either through a direct effect of ethynyl estradiol on the liver or secondary to other hormonal changes.
This research was supported by Grants-in-aid from the Florida Heart Association 73-AG-6 and 74-AG-11. We are grateful to Dr. E. Forchielli of the Syntex Corporation, Palo Alto, California for supplying ethynyl estradiol, and to Dr. W. W. Thatcher, Department of Dairy Science, University of Florida for his aid in performing the corticosterone assays.
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