Abstract
Summary
Newborn rats were made tolerant to human cell antigens by intravenous injection of Amnion B cells, a permanent human cell line of normal origin. At various intervals thereafter each animal, and non-tolerant litter mate controls were challenged by SC and IV injections of the malignant human cell line J-111. Tumor nodules of J-111 cells grew SC and in the lungs of most of the tolerant rats challenged at ages from 7 to 14 days, but not in their controls. Challenge at age 19 days produced SC tumors but there was no growth from the IV inoculum.
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