Preservation of Estrogen-Induced Increase of Uterine Blood Volume Following Catecholamine and Mast Cell Histamine Depletion 1

Abstract

Summary

Uterine blood volume increases after administration of estrogen to ovariec-tomized mice. The effect on uterine blood volume was not altered by depletion of mast cell histamine with compound 48/80 or by depletion of norepinephrine from uterine nerves by 6-hydroxydopamine. Thus, neither reduction in the adrenergic transmitter content nor release of mast cell histamine appears to play any primary role in mediating the changes in uterine hemodynamics produced by estrogen, at least as they are reflected by changes in uterine blood volume.