Abstract
Summary
Cell free Ehrlich ascitic fluid from tumor bearing mice and the nutrient medium from Ehrlich cells maintained in vitro contain a factor (s) which when transferred to normal mice delays rejection of skin allografts and enhances the growth of a syngeneic transplantable tumor. Both types of preparations inhibit DNA synthesis in lymphocytes stimulated by PHA. These results suggest that Ehrlich tumor cells release a factor which impairs the normal lymphocytic response to allo and tumor antigens.
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