Abstract
Summary
The effect of obesity on the connective tissue composition of skin was investigated in mice with goldthioglucose (GTG)-induced obesity. Four months after GTG treatment, the obese animals were sacrificed. Acid mucopolysaccharides, glyco-proteins, collagen, and elastin were analyzed in the skin and compared to the controls. Total MPS in the skin from obese animals decreased, reflected mostly in hyaluronic acid. Chondroitin showed an increase over controls. The content of soluble glycopro-teins varied; total carbohydrate and sialic acid of the glycoprotein tended to increase with obesity. Collagen and elastin both tended to decrease with obesity.
The authors thank F. Piavidal and F. E. Brickman for their assistance and suggestions and Barbara Lynch, Ph.D., for editing the manuscript.
This work was supported by funds from the United States Public Health Service, National Heart and Lung Institute (HL 02942) and the Specialized Center of Research—Arteriosclerosis (HL 15013) and the Louisiana Heart Association.
Get full access to this article
View all access options for this article.