Antiprostatic Effects of a Nitrogen Mustard of Estriol 1

Abstract

Summary

The chemical ester of a nitrogen mustard with estriol was tested for its antiprostatic effects in dogs and rats. The E₃-mustard was shown to interfere with the uptake of labeled estriol in the dog prostate and by the ventral prostate of the rat; and to increase the uptake of the radioactivity associated with testosterone in the dog prostate. The weights of the ventral and dorsolateral prostates of the rat were significantly reduced following the administration of E₃-mustard for 2 days. The results are interpreted to be very similar to those obtained with the mustard of E₂ (Estracyt) and the effects are probably a combination of the actions of the released estrogen (E₃) and/or mustard, either adting individually or in concert.