Distribution and Metabolism of 3 H-2,5,2′,5′-tetrachlorobiphenyl in Rats 1

Abstract

Summary

Distribution and metabolism of an isomeric polychlorinated biphenyl were determined in rats. Over 70% of a single dose of ³H-2,5,2′,5′-tetrachlorobi-phenyl was excreted in the feces and another 13% in the urine during a 14-day period. Adipose tissue, blood, skin, and liver were found to contain low levels of the compound.

Over 90 % of the excreted tritiated compound was found to be metabolized, the major metabolite being identified as 3-OH-2,5,2′, 5′-tetrachlorobiphenyl. All of the un-metabolized 2,5,2′, 5′-tetrachlorobiphenyl was eliminated by the alimentary route.