Abstract
Summary
The effect of Quinestrol, an estrogenic substance of long-lasting activity, on the pituitary responsiveness to LH-RH was studied in ovariectomized rats. Quinestrol administered as a single 200 μg-dose significantly augmented the pituitary response to LH-RH 36 hr, 9 days, and, although not significantly, also at 24 days after its oral administration. No effect could be detected 36 days after its administration. At a 20 μg-dose Quinestrol significantly augmented the pituitary response to LH-RH only at the 36 hr-period studied, this effect not being apparent in later time periods.
The authors are grateful to Dr. G. D. Niswender, Dr. L. E. Reichert, and NIAMDD, Rat Pituitary Program, for the gift of materials used in LH radioimmuno-assays. Thanks are also given to Dr. R. Geiger and Dr. J. Sandow, Hoechst AG, for the gift of synthetic LH-RH, to Laboratorio Endocrinico Argentino (ELEA) for the provision of Quinestrol, to Mr. Carlos Villegas Vélez for his excellent technical help, and to Miss M. Garcia Ben for the statistical analysis.
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