Abstract
Summary
The effect of the acute or chronic administration of sulpiride on serum prolactin and gonadotropin levels was studied in castrated male rats. Sulpiride administered in acute intravenous injections induced a quick increase in serum prolactin levels and no significant changes in serum gonadotro-pins. The peak in serum prolactin was observed 30 min after the injection of sulpiride, with a decrease of serum prolactin levels at 60 and 120 min. The subcutaneous administration of sulpiride for 13 days induced a significant increase in serum prolactin levels at the end of the treatment, and no significant changes in serum FSH and LH levels.
The authors are grateful to Drs. G. D. Niswender, L. E. Reichert, and to the N.I.A.M.D.D. Rat Pituitary Program, for the gift of materials used in radioim-munoassays and to Miss M. Garcia Ben for the statistical analysis of the data.
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