Abstract
Summary
The present report confirms the findings by Steinberg et al. (9) that repeated intraperitoneal injections of poly I:C (3 μg/g, three times per wk, 40-52 doses) enhanced the incidence and severity of glomer-ular lesions that occur spontaneously in NZB/NZW mice and also increased the development of circulating antibody against nucleic acids. This effect was minimal when only six intraperitoneal doses were given in 1 μg/g amount at weekly intervals. Intra-nasal administration of poly I:C (0.2 μg/g, three times per wk, 40 doses) or six doses of the drug (1 μg/g weekly) caused no apparent potentiation of glomerular response. ICR/ Ha mice, which do not suffer from the spontaneously occurring disease, were unaffected by poly I:C treatment except for occasional development of antibody against poly I:C or DNA.
Skilled technical assistance was provided by M. E. Davies, H. Perry, F. Roach, W. P. M. Fisher, M. Johnston, R. Civera, J. A. Duddy, and S. H. Kulp.
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