Abstract
Summary
In dogs with pancreatic fistulas, the amount of CCK released by acid in the intestine was estimated by determining how much exogenous CCK had to be given to mimic the pancreatic protein response. Duodenal infusion of 16 mmole/hr of HC1 with a high background dose of intravenous secretin stimulated pancreatic protein secretion to about the same degree as 0.5 unit/ kg-hr of exogenous CCK; the same acid load without secretin background gave a response equivalent to about 0.7 unit/kg-hr of CCK. Expressed as fractions of their respective doses for half maximal response, acid releases almost five times more secretin than CCK.
We thank John Washington for expert technical assistance. This study was supported in part by a Veterans Administration Senior Medical Investigatorship (MIG) and by National Science Foundation Grant No. GB 40370. Dr. Barbezat held an International Postdoctoral Fellowship from USPHS (FOS-TW-1616-01).
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