Abstract
Summary
Vomition is the most consistent response to oral SEB challenge in the monkey. The technique of cross-circulation clearly differentiates local neural phenomenon from humoral mechanisms. Our results support the theory that SEB-induced vomition follows stimulation of local neural receptors in the gut. The evidence indicates no significant amount of enterotoxin absorption or stimulation of vomition by any centrally acting humoral mechanism.
The authors thank Dr. Virginia McGann for advice helpful in this work; Mr. Michael Griffin, Mr. Glenn Crone and Miss Karen Bostian for chemical analysis; and PFC Jack Condon and PFC Clair Meske for technical assistance.
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