Abstract
Summary
Administration of aminophyl-line to intact rats did not cause a change in serum Ca, but did cause a significant increase in serum PTH. Administration of EDTA alone caused hypocalcemia, and a greater increase in PTH than that caused by amino-phylline alone. Aminophylline plus EDTA given together caused no greater hypocalcemia, but a significantly greater increase in PTH than that caused by EDTA alone. Therefore, aminophylline increased PTH secretion when given alone, and also enhanced the PTH secretion stimulated by EDTA-induced hypocalcemia in vivo.
We thank Mrs. Bertha L. Jackson for technical assistance; Miss Joanne C. Vaccaro and Mrs. Anna B. Baker for their secretarial assistance.
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