Abstract
Summary
Analytical ultracentrifugation showed Cebus and Rhesus monkeys had two low density components while only one was present in Squirrel monkeys. In untreated or W1372 treated monkeys, neither chylomicrons nor very low density lipo-proteins were detected on analytical ultra-centrifugation. Chylomicrons were not observed on agarose gel electrophoresis.
Ultracentrifugal analysis showed W1372 treatment decreased the amount of LDL in all animals and also the HDL in Cebus monkeys on an atherogenic diet. Both untreated and W1372 treated Cebus monkeys on an atherogenic diet had abnormal amounts of LDL and HDL, while the LDL in treated animals occurred as multiple peaks. This was also evident on agarose gel electrophoresis. Accumulation of lipids in the liver and decrease of serum lipids indicated W1372 prevented release of lipopro-teins from the liver.
The authors wish to thank Mrs. Christine Brod-beck, J. Giroux, and K. Carpenter for their skilled assistance.
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