Abstract
Summary
The intraperitoneal administration of tetracycline (TCL) to female Wistar rats in graded doses ranging from 100 to 300 mg/kg led to the development of small-droplet fatty metamorphosis by 24 hr and to modest, dose-related, increased serum levels of glutamic-oxalactic transaminase (SGOT). A dose of 50 mg/kg of TCL led to an increase in the SGOT level but not to demonstrable fatty metamorphosis. Serum levels of glutamic pyruvic transaminase were found to be less sensitive than those of SGOT as a reflection of the hepatic injury. Serum levels of glutamic dehydrogenase, acid and alkaline phosphatase, β-glucuronidase, and bilirubin remained normal.
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