Abstract
Summary
Using permanent stalk-sectioned-ovariectomized rats and 4-day cyclic rats on the day of estrus, the effect of either subcutaneous or acute intravenous intracarotid LH-RH was examined. After a subcutaneous injection of LH-RH both FSH and LH release occurred, whereas only LH levels increased after an intravenous or intra-arterial injection. These results suggest that prolonged exposure of the pituitary to LH-RH is necessary for FSH discharge, or that LH-RH may undergo metabolic modifications resulting in greater FSH releasing activity.
This research was supported in part by the Training Grant No. HD 00112-06 and Research Grant No. HD 04626-13 from the National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD.
Get full access to this article
View all access options for this article.