Abstract
Summary
Conditioning of gastric secretion was studied in rats using epinephrine as unconditioned stimulus. Although epinephrine itself produced a marked inhibition of gastric secretion, a conditioned paradoxical increase was noted during the 1-hr period of observation immediately prior to drug administration. It appears that the initial increase of secretion during the sessions of drug phase occurred as a result of an adaptive compensatory mechanism in anticipation of its marked inhibition.
This work was supported by USPHS Grant No. BM-17824. Authors gratefully acknowledge the help of Dr. S. L. Schwartz of Georgetown University School of Medicine for statistical analysis.
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