Abstract
Summary
Dual infection with endogenous herpes- and C-type viruses in cultured cells derived from normal guinea pigs as well as in single guinea pig cells, was observed. The guinea pig C-type virus was activated by maintenance of the cultured cells in BrdU containing medium and was detected in all guinea pigs tested, regardless of age, strain or source of animals. Manifestation of the herpesvirus required prolonged cultivation of the cells or co-cultivation with susceptible monolayer cultures. The herpesvirus isolation was age and strain dependent; it occurred most frequently in older inbred animals.
Note added in proof: Guinea pig No. AD 185 showed GPHLV infection when tested at 11 mo. Furthermore, both GPHLV and C-type virus were observed in cultured spleen and/or kidney cells derived from leukemic guinea pigs.
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