Effect of Phenylalanine and p -Chlorophenylalanine Administration on the Development of Rat Brain 2′,3′-Cyclic Nucleotide 3′-Phosphohydrolase 1

Abstract

Summary

Subcutaneous injections of L-phenylalanine and DL-p-chlorophenylalanine in developing rats resulted in reduced body weight, brain weight, and concentration of 2′,3′-cyclic nucleotide 3′-phosphohydrolase—a myelin-enriched protein. These reductions were less marked when injections were reduced by half; when pups were allowed to recover after age 13 days, no differences were observed at 40 days of age. Brain hexokinase and cytochrome c oxidase development was not affected by the injection treatments.