Histamine Sensitization of Mice by Trichinella spiralis Infection

Abstract

Summary

Infection of mice with T. spiralis larvae collected from infected muscle induce a state of histamine hypersensitivity in CFW mice. This hypersensitivity can be detected 14 days after oral infection with larvae, and coincides with the time when larvae from the adult female penetrate the intestinal wall and first appear in striated muscle. The LD₅₀ of histamine for infected mice was 0.1785 mg, which is of the same order of magnitude as the LD₅₀ in mice treated with histamine sensitizing factor of B. pertussis. The hypersensitivity induced by T. spiralis seems to be long lasting.