Abstract
Summary
Immunological studies of the thrombopoietic stimulating factor (TSF) have been described. The experiments indicated that the thrombopoietic activity of TSF, as assayed in the immunothrombocythemic mouse, was neutralized in vitro by addition of serum obtained from a rabbit previously immunized with a TSF-rich preparation. The anti-TSF serum had no effect on platelets; however, a depression in thrombopoiesis was observed after injection of anti-TSF serum into normal mice. It is concluded that the injections into normal mice of an antibody developed against the TSF, interrupts normal thrombopoiesis by reducing endogenous TSF levels.
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