Abstract
Summary
The blockading of RES with carbon particles prior to the administration of di-methylnitrosamine prevented the damage of the liver cells caused by the drug. Histological observations revealed that both parenchymal and endothelial cells of the liver were protected. However, simultaneous treatment with carbon particles had no protective effect and the post-treatment was even deleterious. Blockading of RES with saccharated ferric oxide also protected the animals from the lethal effect of DMN to some extent.
From these results, it is suggested that the reinforcement of blood vessels and sinusoids of the liver is responsible for the protection of liver parenchyma from the toxicities.
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