Abstract
Summary
Interactions between methylene blue (MB) and erythrocytes of the cat, dog, and man were studied in vitro. Feline red blood cells (RBC) were more susceptible to Heinz body formation in the presence of MB than those of the other species. Erythrocytes of the cat and dog were unable to concentrate MB intracellularly as readily as human RBC. In addition, feline and canine RBC were unable to maintain their reduced glutathione (GSH) at preincubation levels when incubated with MB at a concentration which produced no significant decrease in GSH in human cells. These differences in dye concentration and glutathione “instability” are discussed in relation to the greater susceptibility of feline erythrocytes to Heinz body formation.
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