Abstract
Summary
Glucagon treatment for 10 days induced rat liver phenylalanine:pyruvate amino-transferase approximately eightfold but did not result in increased urinary phenylpyruvate excretion by rats administered a phenylalanine load after they had been injected with an amount of glucagon sufficient to induce the enzyme substantially. In fact, an inverse correlation was observed between phenylpyruvate excretion and aminotransferase activity. Hepatic phenylalanine hydroxylase was not induced in rats treated for 10 days with glucagon. It is suggested that hepatic phenylalanhe:pyruvate aminotransferase does not function as such in vivo.
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