Abstract
Summary
A method is described for the measurement of uterine blood volume using RIHSA as a tracer. Estrus induced by 2-day administration of estrogen to ovariectomized mice or normally occurring estrus in mice was associated with a parallel increase in uterine weight and uterine blood volume. This increase may be attributed to either increased vascularity or increased vascular capacitance. After acute administration of estrogen to ovariectomized mice and rats, uterine blood volume increased without a corresponding change in uterine weight. This change occurred when the uterus was visibly hyperemic and at a time which corresponds roughly to that when uterine blood flow has been shown to increase. Changes in the volume measured with protein were demonstrated to be valid and to not result from increased vascular permeability.
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