Abstract
Summary
Using a transplantable SV40 tumor system in hamsters, we evaluated the immunoprophylactic and immunotherapeutic properties of lyophilized Glaxo-strain and fresh frozen Phipps-strain BCG. These results were correlated with growth-culture kinetics, virulence, and colony morphology of the two preparations. The results demonstrate an immunoprophylactic effect with Phipps, as measured by delay of appearance and reduction of total tumor incidence. An actual enhancement of tumor incidence was obtained with the Glaxo strain. In combination with irradiated tumor cells, both had synergistic effects on the development of transplantation immunity in the hamster. However, the effect of the Glaxo strain was significantly lower than that of the Phipps strain.
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