Abstract
Summary
Intravascular phagocytic clearance of colloidal carbon and a “RE-test-lipid emulsion” was comparable to that reported for the rat, mouse, and dogs. Clearance of′ a RE-test-lipid emulsion 3 hr after injection of an initial dose was markedly depressed. However, preopsonization of the emulsion with normal cat plasma prior to injection significantly prevented this depression. Phagocytosis of cat liver slices in vitro was found to be dependent on the amount of normal cat plasma in the incubation medium. As the concentration of plasma in the incubation medium was increased, the degree of phagocytic uptake of the RE-test-lipid emulsion increased proportionately. Heat treatment of normal cat plasma destroyed its phagocytic supporting property. Finally, it was found that hemorrhagic hypotension results in about a 50% depression in the clearance of colloidal carbon as compared to nonhemorrhaged controls. The evidence is consistent with the hypothesis that serum opsonins and/or RES-dependent substances may be involved in depression of RES function in post-oligemic shock.
Get full access to this article
View all access options for this article.