Abstract
Summary
The effect of intravenous acetylcholine upon serum gastrin in normal dogs, dogs with gastric fistulas and dogs with total gastrectomy has been studied. No alteration in serum gastrin was seen in normal dogs or dogs with total gastrectomy. In dogs with gastric fistulas significant increases in serum gastrin were seen with supratoxic doses of acetylcholine. Acid secretion from gastric fistulas occurred before the onset of toxic signs and before the increases in serum gastrin. It is concluded that: (a) intravenous acetylcholine can stimulate gastric secretion without increasing serum gastrin, (b) supratoxic doses of intravenous acetylcholine stimulate release of gastrin but only if gastric acid is removed, and (c) gastrin which is released came from the gastric antrum.
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