Abstract
Summary
Rabbits were fed a diet containing 1% cholesterol-3 % peanut oil for 13 weeks. It was found that blood basophil count, serum triglyceride and cholesterol increased during the development of atherosclerosis. The changes of blood basophil number showed a significant correlation with the changes of serum triglyceride level but less correlation with serum cholesterol. The major component in the mucopolysac-charide extracts of the rabbit blood basophils was identified as chondroitin sulphate A/C. The sulphated mucopolysaccharide content per basophil decreased in the course of hyperlipemia and hypercholesterolemia. These findings give evidence of the physiological role of basophils in metabolism of triglycerides.
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