Interrelationships of Iron and Cobalt Absorption: Mucosal Distribution of Cobalt During Absorption

Abstract

Summary

The carcass transfer and subcellular distribution of cobalt during the period of rapid absorption were studied in normal rats and animals with iron deficiency or phenylhydrazine induced hemolytic anemia. Although carcass transfer of cobalt was increased in the latter 2 groups, no binding to soluble cytoplasmic molecules was found. Since iron and cobalt appear to share a common absorptive mechanism, these findings support the proposition that soluble cytoplasmic molecules do not play a major role in the control of absorption of these cations.