Abstract
Summary
Ethanol inhibited markedly the hyperglycemic response to isoproterenol in the fasted rat, whereas the hyperglycemic response to epinephrine was not changed significantly. Since ethanol is a potent inhibitor of gluconeogenesis, these data give support to the suggestion that isoproterenol produces its hyperglycemic effect in the fasted rat by mechanisms involving gluconeogenesis. Furthermore, this work suggests that isoproterenol-induced hyperglycemia in the fasted rat may provide an animal model for testing other inhibitors of gluconeogenesis.
Get full access to this article
View all access options for this article.