Abstract
Summary
Studies were conducted to assess renal transport functions in chickens which had undergone genetic selection for a high (HUA line) or low (LUA line) incidence of hyperuricemia and articular gout. It was found previously that uric acid secretion was markedly reduced in chickens of the HUA line. In the present studies the rates of glomerular filtration, tubular reabsorption of arginine and glucose, and tubular secretion of tetraethylammonium and creatinine were not significantly different between chickens of the two lines. The rate of secretion of PAH in chickens of the HUA line, however, was approximately 40% of the rate for chickens of the LUA line. These results suggest that renal impairment in hyperuricemic chickens is specific for organic acid transport.
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