Seromucoid and Albumin Syntheses After Uninephrectomy and Partial Hepatectomy in the Rat

Abstract

Summary

After UNX, seromucoid synthesis represents an increasing proportion of total plasma protein synthesis. The increase reaches a sharp peak at 48 hr and rapidly diminishes. This pattern is distinct from those produced by either simple laparotomy or PHX. The seromucoid response is apparently not related to the renal hyperplastic response but is more likely a direct result of the UNX itself. After SO or PHX, relative albumin label drops. This is not observed for the first day after UNX. This may be the result of a transient increase in albumin synthesis. When UNX and PHX are done in the same animal, there is some inhibition of the respective hyperplasias but no interference with the expected restoration of lost tissue.

This work was supported, in part, by the Susan B. Thomas Memorial Fund.