Abstract
Summary
A progressive increase in plasma fibrinogen and haptoglobin occurred in rats receiving increasing doses of leuko-cytic endogenous mediator. The increases in fibrinogen occurred sooner after injections of leukocytic endogenous mediator than with endotoxin injections. Neither endo-toxin nor leukocytic endogenous mediator caused increased radioactive glycine incorporation into fibrinogen when incubated directly with the liver in vitro. Both of them when injected into the rat caused a rapid release of a humoral material into the plasma which stimulated in vitro glycine incorporation into fibrinogen.
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