Abstract
Summary
Gentamicin nephrotoxicity was examined in normal rats and in rats chronically ingesting 1% NH4C1 solution. Metabolic acidosis significantly exacerbated gentamicin nephrotoxicity as manifested by elevation of SUN and depression of tissue uptake of PAH and TEA by renal cortical slices. In contrast normal rats given the same dose of gentamicin did not develop nephrotoxicity. Pathological examination confirmed that acute tubular necrosis occurred only in the acid-loaded rats injected with gentamicin.
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