Abstract
Summary
The growth characteristics of Novikoff hepatoma cells growing in culture can be differentially altered by the addition of long-chain fatty acids to the growth medium. The greatest reduction in growth rate was obtained by adding sodium stearate to the growth medium and the least was when sodium oleate was added; the effect of sodium petroselenate was intermediate. The addition of the methyl ester to the growth medium caused a smaller reduction in cell proliferation than the corresponding sodium salt of the fatty acid.
When each of the long-chain acids in their triglyceride form was added to the growth medium, there was no reduction in the growth rate of the cells even at very high concentrations. Possible reasons for these changes are discussed.
This investigation was supported by Public Health Service Grant HL 08214 from the Program Projects Branch, Extramural Programs, National Heart and Lung Institute, Grant CA 14003 of the National Cancer Institute and The Hormel Foundation.
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