Abstract
Summary
The effects of infusion of synthetic thytropin releasing hormone (TRH) into a hypophysial portal vessel on the release of prolactin and growth hormone (GH) were investigated in normal male rats under urethane anesthesia. Significant increases in serum prolactin and GH levels were consistently observed after the infusion of 100 ng or larger doses of synthetic TRH, but smaller doses had no effect. Pretreat-ment of rats with 50 fig estradiol in oil raised the basal levels of prolactin and GH, but the net increase after TRH remained the same for prolactin and was somewhat reduced for GH.
The authors are indebted to Mrs. J. Gauthier and Mrs. M. Esslinger for their excellent technical assistance, Dr. Abba J. Kastin for his help in preparing the manuscript, and NIAMD Rat Pituitary Hormone Program for the supply of rat GH and Prolactin RIA Kits.
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