Abstract
Summary
The purine analogue, 8-azaguanine, inhibits the induction of uterine glucose-6-P dehydrogenase (D-glucose-6-phosphate: NADP+ oxidoreductase, EC 1.1.1.49) by estradiol or the enzyme's co-factor, NADP+. Inactivation of the enzyme after estradiol withdrawal was not affected by 8-azaguanine treatment. Since 8-aza-guanine limited the uterine response to estradiol when injected at any time after the steroid, the RNA necessary for the synthesis of uterine glucose-6-P dehydrogenase must be synthesized continuously after the initiation of the uterine response to estradiol.
This research was supported by USPHS Research Grant (HD-02,851), National Institute of Child Health and Human Development.
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