Abstract
Summary
Abdominal aortic blood flow and hindquarter vascular resistance were determined in young (2-3 mo) spontaneously hypertensive rats (SHR) and in age-matched Wistar Kyoto (WKY) normo-tensives. Abdominal aortic blood flow was similar in the 2 groups, whereas hindquarter vascular resistance was elevated in the SHR compared to WKY. Additionally, in the open-chest preparation there was no significant difference in ascending aortic blood flow between hypertensives and normoten-sives, while total peripheral resistance was increased in the SHR relative to WKY. These data suggest that early in the development of hypertension in the SHR the hemodynamic pattern of normal blood flow and elevated resistance exists in the hindquarter vasculature and the total systemic circulation.
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