Abstract
Summary
Subchronic (90 day) toxicity of N-2-fluorenylacetamide has been investigated in male and female C57BL/6j and BALB/cStrCr1BR strain mice. No signs of toxicity were observed with dietary levels ranging from 0.001-0.05% 2-FAA. A dose dependent urinary bladder epithelial hyperplasia was seen in both strains with the males being more susceptible than the females. Squamous metaplasia of the urinary bladder was observed in the BALB/c mice with the male response being double that of the female. One urinary bladder carcinoma was found in a BALB/c male at the 0.025 and 0.05% 2-FAA levels. Adrenal gland spindle cell hyperplasia was more pronounced in the females of both strains. Males of both strains had urinary bladder concretions. No other significant histopathological changes were observed.
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