Abstract
Summary
Plaque-derived clones of Crimean hemorrhagic fever-Congo (CHF-C) and Hazara viruses were randomly selected in LLC-MK2 cell cultures. Results of cross plaque neutralization tests with the cloned viruses and their respective hyperimmune mouse sera showed a definite and reproducible relationship between the viruses, confirming observations with complement-fixation and hemagglutination-inhibition tests. CHF-C virus inhibitory substance was removed by acetoneether treatment of sera; specific antibody titer was not affected by the method.
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