Abstract
Summary
The plasma half-life of propranolol after intramuscular injection is 100 min in the New Zealand female rabbit. After the administration of a single dose of propranolol. there is a lowering of plasma renin activity (PRA) and an inverse correlation between PRA and plasma propranolol. It appears that the effect of propranolol on PRA is related to the plasma level of the drug which directly relates to the time of the last administration of the drug.
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