Abstract
Summary
To determine the effect of acute administration of high concentrations of ethanol on duodenal calcium transport, experiments were performed using an in vitro everted gut sac technique. One hour after the administration of ethanol intragastrically, significant decreases in transport and necrosis of epithelium were produced while intraperitoneal administration resulted in no changes. Similar changes were observed after the addition of ethanol to the incubation system. The results suggest that the inhibition of calcium transport seen after acute administration of ethanol is the result of a direct toxic effect on the intestinal epithelium.
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