Abstract
Summary
The rate of clearance of iv-injected human leukocyte interferon from the blood of rabbits was not affected by induction of endogenous interferon with NDV injected 1, 6, or 24 hr earlier. Likewise, im injection of the human interferon into rabbits together with, or at different times after NDV induction, gave a clearance pattern of circulating interferon similar to that in control rabbits.
Administration of exogenous human or rabbit interferon to rabbits injected previously with NDV resulted in increased toxicity.
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